Assay Detail
Functional
CHEMBL815868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested in vitro for inhibitory activity against type 2 5-alpha reductase Isozyme homogenated from rat epididymis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL5099) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Indole derivatives as a new class of steroid 5 alpha-reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.12 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90085 | — | — | 1 | 6.55 |
| CHEMBL347059 | — | — | 1 | 6.12 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90085 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL347059 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL710 | FINASTERIDE | IC50 | = | 2100.0 | nM | 5.68 |