Assay Detail
Functional
CHEMBL815878
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Cytotoxic activity was evaluated against U87MG tumor cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.94 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170758 | — | — | 1 | 8.68 |
| CHEMBL318721 | — | — | 1 | 8.10 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.96 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.66 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170758 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL318721 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 48.0 | nM | 7.32 |