Assay Detail
Binding
CHEMBL815924
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 39 | 8.52 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31146 | — | — | 1 | 10.30 |
| CHEMBL31765 | — | — | 1 | 10.00 |
| CHEMBL30743 | — | — | 1 | 9.70 |
| CHEMBL30615 | — | — | 1 | 9.70 |
| CHEMBL281959 | — | — | 1 | 9.52 |
| CHEMBL283923 | — | — | 1 | 9.52 |
| CHEMBL29429 | — | — | 1 | 9.30 |
| CHEMBL30972 | — | — | 1 | 9.22 |
| CHEMBL410732 | — | — | 1 | 9.15 |
| CHEMBL31922 | — | — | 1 | 9.15 |
| CHEMBL281726 | — | — | 1 | 9.10 |
| CHEMBL31154 | — | — | 1 | 9.07 |
| CHEMBL286978 | — | — | 1 | 9.00 |
| CHEMBL285596 | — | — | 1 | 8.92 |
| CHEMBL278159 | — | — | 1 | 8.89 |
| CHEMBL30398 | — | — | 1 | 8.80 |
| CHEMBL31850 | — | — | 1 | 8.54 |
| CHEMBL287068 | — | — | 1 | 8.54 |
| CHEMBL30832 | — | — | 1 | 8.49 |
| CHEMBL30537 | — | — | 1 | 8.41 |
| CHEMBL283100 | BMS-180291 | — | 1 | 8.40 |
| CHEMBL31334 | — | — | 1 | 8.35 |
| CHEMBL416943 | — | — | 1 | 8.33 |
| CHEMBL281293 | — | — | 1 | 8.32 |
| CHEMBL418585 | — | — | 1 | 8.24 |
| CHEMBL433435 | — | — | 1 | 8.00 |
| CHEMBL416395 | — | — | 1 | 7.97 |
| CHEMBL418583 | — | — | 1 | 7.96 |
| CHEMBL280786 | — | — | 1 | 7.79 |
| CHEMBL286708 | — | — | 1 | 7.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31146 | — | Kd | = | 0.05 | nM | 10.30 |
| CHEMBL31765 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL30615 | — | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL30743 | — | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL281959 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL283923 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL29429 | — | Kd | = | 0.5 | nM | 9.30 |
| CHEMBL30972 | — | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL410732 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL31922 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL281726 | — | Kd | = | 0.8 | nM | 9.10 |
| CHEMBL31154 | — | Kd | = | 0.85 | nM | 9.07 |
| CHEMBL286978 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL285596 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL278159 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL30398 | — | Kd | = | 1.6 | nM | 8.80 |
| CHEMBL31850 | — | Kd | = | 2.9 | nM | 8.54 |
| CHEMBL287068 | — | Kd | = | 2.9 | nM | 8.54 |
| CHEMBL30832 | — | Kd | = | 3.2 | nM | 8.49 |
| CHEMBL30537 | — | Kd | = | 3.9 | nM | 8.41 |
| CHEMBL283100 | BMS-180291 | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL31334 | — | Kd | = | 4.5 | nM | 8.35 |
| CHEMBL416943 | — | Kd | = | 4.7 | nM | 8.33 |
| CHEMBL281293 | — | Kd | = | 4.8 | nM | 8.32 |
| CHEMBL418585 | — | Kd | = | 5.8 | nM | 8.24 |
| CHEMBL433435 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL416395 | — | Kd | = | 10.6 | nM | 7.97 |
| CHEMBL418583 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL280786 | — | Kd | = | 16.3 | nM | 7.79 |
| CHEMBL286708 | — | Kd | = | 18.4 | nM | 7.74 |
| CHEMBL31043 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL287421 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL30727 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL30377 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL2368531 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL29947 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL282186 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL33621 | — | Kd | = | 45.0 | nM | 7.35 |
| CHEMBL282601 | — | Kd | = | 112.0 | nM | 6.95 |