Assay Detail
Binding
CHEMBL815977
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In vitro inhibition of HWMT human urokinase Plasminogen activator.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 4.83 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293098 | — | — | 1 | 5.54 |
| CHEMBL54357 | — | — | 1 | 5.50 |
| CHEMBL55125 | — | — | 1 | 5.32 |
| CHEMBL292900 | — | — | 1 | 5.26 |
| CHEMBL41040 | — | — | 1 | 5.17 |
| CHEMBL54467 | — | — | 1 | 5.15 |
| CHEMBL55808 | — | — | 1 | 5.06 |
| CHEMBL298989 | — | — | 1 | 5.00 |
| CHEMBL128047 | — | — | 1 | 4.53 |
| CHEMBL53031 | — | — | 1 | 4.49 |
| CHEMBL52361 | — | — | 1 | 4.42 |
| CHEMBL53032 | — | — | 1 | 4.39 |
| CHEMBL55184 | — | — | 1 | 4.27 |
| CHEMBL300135 | — | — | 1 | 4.21 |
| CHEMBL54640 | — | — | 1 | 4.08 |
| CHEMBL54989 | — | — | 1 | - |
| CHEMBL54545 | — | — | 1 | - |
| CHEMBL55051 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293098 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL54357 | — | Ki | = | 3130.0 | nM | 5.50 |
| CHEMBL55125 | — | Ki | = | 4830.0 | nM | 5.32 |
| CHEMBL292900 | — | Ki | = | 5470.0 | nM | 5.26 |
| CHEMBL41040 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL54467 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL55808 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL298989 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL128047 | — | Ki | = | 29500.0 | nM | 4.53 |
| CHEMBL53031 | — | Ki | = | 32300.0 | nM | 4.49 |
| CHEMBL52361 | — | Ki | = | 37700.0 | nM | 4.42 |
| CHEMBL53032 | — | Ki | = | 40700.0 | nM | 4.39 |
| CHEMBL55184 | — | Ki | = | 53300.0 | nM | 4.27 |
| CHEMBL300135 | — | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL54640 | — | Ki | = | 83800.0 | nM | 4.08 |
| CHEMBL54989 | — | Ki | = | 292000.0 | nM | - |
| CHEMBL54545 | — | Ki | = | 173000.0 | nM | - |
| CHEMBL55051 | — | Ki | = | 147000.0 | nM | - |