Compound Detail
CHEMBL128047
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Basic Information
| ChEMBL ID | CHEMBL128047 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NVDXVBPBFJKQJG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
136.2
MW (Da)
0.39
ALogP
2
HBA
3
HBD
74.8
PSA (Ų)
0.39
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 4.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Urokinase-type plasminogen activator CHEMBL3286 | Ki | 4.54 | 4.535 | 29000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Urokinase-type plasminogen activator | Ki | = | 29000.0 | nM | 4.54 | Inhibitory activity against human urokinase-type plasminogen activator was evalu... | 15149680 |
| Urokinase-type plasminogen activator | Ki | = | 29500.0 | nM | 4.53 | In vitro inhibition of HWMT human urokinase Plasminogen activator. | 11755349 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8831767 | 10.1021/jm9603936 | Serotonin 3 (5-HT3) receptor | 1 |
| 11755349 | 10.1016/s0960-894x(01)00701-6 | Urokinase-type plasminogen activator | 1 |
| 11755349 | 10.1016/s0960-894x(01)00701-6 | Tissue-type plasminogen activator | 1 |
| 11755349 | 10.1016/s0960-894x(01)00701-6 | Plasminogen | 1 |
| 15149680 | 10.1016/j.bmcl.2004.03.094 | Urokinase-type plasminogen activator | 1 |
| 15149680 | 10.1016/j.bmcl.2004.03.094 | Tissue-type plasminogen activator | 1 |
| 15149680 | 10.1016/j.bmcl.2004.03.094 | Plasminogen | 1 |
Data from ChEMBL 36 via Core Engine