Assay Detail
Binding
CHEMBL815981
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Binding affinity to human urokinase-type plasminogen activator (microPa).
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.78 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108447 | — | — | 1 | 8.20 |
| CHEMBL111567 | — | — | 1 | 7.78 |
| CHEMBL418839 | — | — | 1 | 7.66 |
| CHEMBL442201 | — | — | 1 | 7.63 |
| CHEMBL111338 | — | — | 1 | 7.58 |
| CHEMBL111575 | — | — | 1 | 7.55 |
| CHEMBL111543 | — | — | 1 | 7.55 |
| CHEMBL323387 | — | — | 1 | 7.45 |
| CHEMBL111432 | — | — | 1 | 7.42 |
| CHEMBL324168 | — | — | 1 | 7.40 |
| CHEMBL109367 | — | — | 1 | 7.32 |
| CHEMBL111471 | — | — | 1 | 7.20 |
| CHEMBL108098 | — | — | 1 | 7.09 |
| CHEMBL111629 | — | — | 1 | 6.98 |
| CHEMBL109535 | — | — | 1 | 6.91 |
| CHEMBL112995 | — | — | 1 | 6.86 |
| CHEMBL323785 | — | — | 1 | 6.79 |
| CHEMBL110026 | — | — | 1 | 6.78 |
| CHEMBL111042 | — | — | 1 | 6.63 |
| CHEMBL320749 | — | — | 1 | 6.49 |
| CHEMBL110027 | — | — | 1 | 6.29 |
| CHEMBL104937 | — | — | 1 | 6.20 |
| CHEMBL111660 | — | — | 1 | 6.13 |
| CHEMBL109287 | — | — | 1 | 5.72 |
| CHEMBL105171 | — | — | 1 | 5.23 |
| CHEMBL321666 | — | — | 1 | 5.10 |
| CHEMBL322723 | — | — | 1 | 5.06 |
| CHEMBL111110 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108447 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL111567 | — | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL418839 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL442201 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL111338 | — | Ki | = | 26.5 | nM | 7.58 |
| CHEMBL111575 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL111543 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL323387 | — | Ki | = | 35.5 | nM | 7.45 |
| CHEMBL111432 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL324168 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL109367 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL111471 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL108098 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL111629 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL109535 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL112995 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL323785 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL110026 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL111042 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL320749 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL110027 | — | Ki | = | 517.0 | nM | 6.29 |
| CHEMBL104937 | — | Ki | = | 631.0 | nM | 6.20 |
| CHEMBL111660 | — | Ki | = | 736.0 | nM | 6.13 |
| CHEMBL109287 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL105171 | — | Ki | = | 5910.0 | nM | 5.23 |
| CHEMBL321666 | — | Ki | = | 7980.0 | nM | 5.10 |
| CHEMBL322723 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL111110 | — | Ki | = | 15500.0 | nM | 4.81 |