Assay Detail
Functional
CHEMBL815988
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha production in LPS stimulated human PBMCs
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.84 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114343 | — | — | 1 | 6.42 |
| CHEMBL110421 | — | — | 1 | 6.35 |
| CHEMBL88935 | — | — | 1 | 5.54 |
| CHEMBL111111 | — | — | 1 | 5.38 |
| CHEMBL110956 | — | — | 1 | 5.33 |
| CHEMBL322553 | — | — | 1 | 5.25 |
| CHEMBL110110 | — | — | 1 | 5.12 |
| CHEMBL89890 | — | — | 1 | 4.92 |
| CHEMBL111560 | — | — | 1 | 4.92 |
| CHEMBL113442 | — | — | 1 | 4.82 |
| CHEMBL419204 | — | — | 1 | 4.41 |
| CHEMBL323009 | — | — | 1 | 4.29 |
| CHEMBL111503 | — | — | 1 | 4.28 |
| CHEMBL110949 | — | — | 1 | 4.26 |
| CHEMBL109316 | — | — | 1 | 4.22 |
| CHEMBL111973 | — | — | 1 | 4.21 |
| CHEMBL320347 | — | — | 1 | 4.16 |
| CHEMBL109264 | — | — | 1 | 4.08 |
| CHEMBL321032 | — | — | 1 | 4.05 |
| CHEMBL320567 | — | — | 1 | - |
| CHEMBL111637 | — | — | 1 | - |
| CHEMBL110972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114343 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL110421 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL88935 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL111111 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL110956 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL322553 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL110110 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL89890 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL111560 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL113442 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL419204 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL323009 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL111503 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL110949 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL109316 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL111973 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL320347 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL109264 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL321032 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL320567 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL111637 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL110972 | — | IC50 | = | 150000.0 | nM | - |