Assay Detail
Functional
CHEMBL816010
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Effective concentration range of compound was determined in stimulating Vgamma9 / Vdelta2 T cell
13
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.57 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145233 | — | — | 3 | 9.52 |
| CHEMBL144599 | IODOHYDRIN PYROPHOSPHATE | — | 1 | 8.52 |
| CHEMBL143948 | BROMOHYDRIN PYROPHOSPHATE | — | 1 | 7.70 |
| CHEMBL675 | ALENDRONATE SODIUM | 4.0 | 2 | 6.05 |
| CHEMBL356362 | ISOPENTENYLPYROPHOSPHATE | — | 2 | 5.40 |
| CHEMBL676 | — | — | 2 | 5.10 |
| CHEMBL606077 | PHOSPHORIBOSYL PYROPHOSPHATE | — | 1 | - |
| CHEMBL603367 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145233 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL145233 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL144599 | IODOHYDRIN PYROPHOSPHATE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL143948 | BROMOHYDRIN PYROPHOSPHATE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL675 | ALENDRONATE SODIUM | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL675 | ALENDRONATE SODIUM | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL356362 | ISOPENTENYLPYROPHOSPHATE | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL676 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL145233 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL676 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL356362 | ISOPENTENYLPYROPHOSPHATE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL606077 | PHOSPHORIBOSYL PYROPHOSPHATE | EC50 | > | 10000000.0 | nM | - |
| CHEMBL603367 | — | EC50 | = | 10000000.0 | nM | - |