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Assay Detail

CHEMBL816031

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of [3H]apomorphine binding to dopamine receptor of rat corpus striatum
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Tissue Striatum
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Dopamine receptor (CHEMBL2093868)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Resolution and absolute configuration of an ergoline-related dopamine agonist, trans-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H(or 2H)-pyrazolo[3,4-g]quinoline.
Titus RD, Kornfeld EC, Jones ND, Clemens JA, Smalstig EB, Fuller RW, Hahn RA, Hynes MD, Mason NR, Wong DT, Foreman MM.
J Med Chem (1983) 26 : 1112 -1116
PubMed 6876078 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.80 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL531 PERGOLIDE 4.0 1 8.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL531 PERGOLIDE IC50 = 1.6 nM 8.80