Assay Detail
Binding
CHEMBL816074
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Inhibitory activity against thrombin induced platelet aggregation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.52 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273196 | EFEGATRAN | 2.0 | 1 | 7.64 |
| CHEMBL270437 | — | — | 1 | 7.64 |
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273196 | EFEGATRAN | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL270437 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1166 | ARGATROBAN | IC50 | = | 52.0 | nM | 7.28 |