Assay Detail
Binding
CHEMBL816154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 4.62 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102454 | — | — | 1 | 5.30 |
| CHEMBL102425 | — | — | 1 | 5.16 |
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | — | 1 | 5.00 |
| CHEMBL319447 | — | — | 1 | 4.92 |
| CHEMBL1160604 | — | — | 1 | 4.72 |
| CHEMBL52609 | DOXRIBTIMINE | 2.0 | 2 | 4.57 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 4.55 |
| CHEMBL105318 | ALOVUDINE | 2.0 | 1 | 4.55 |
| CHEMBL1160814 | — | — | 1 | 4.55 |
| CHEMBL1160603 | — | — | 1 | 4.37 |
| CHEMBL1160596 | — | — | 1 | 4.35 |
| CHEMBL322925 | — | — | 1 | 4.05 |
| CHEMBL1129 | TRIFLURIDINE | 4.0 | 1 | 4.01 |
| CHEMBL103283 | — | — | 1 | - |
| CHEMBL105524 | — | — | 1 | - |
| CHEMBL318153 | EDOXUDINE | 2.0 | 1 | - |
| CHEMBL1130 | DOXIFLURIDINE | 3.0 | 1 | - |
| CHEMBL103356 | 3-AMINO- 3-DEOXYTHYMIDINE | — | 1 | - |
| CHEMBL1160818 | — | — | 1 | - |
| CHEMBL54918 | 5-FLUOROURIDINE | 2.0 | 1 | - |
| CHEMBL1160817 | — | — | 1 | - |
| CHEMBL102479 | — | — | 1 | - |
| CHEMBL1160806 | — | — | 1 | - |
| CHEMBL1160597 | — | — | 1 | - |
| CHEMBL1160592 | — | — | 1 | - |
| CHEMBL1160816 | — | — | 1 | - |
| CHEMBL320200 | — | — | 1 | - |
| CHEMBL102768 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102454 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL102425 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL319447 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1160604 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL52609 | DOXRIBTIMINE | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL129 | ZIDOVUDINE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL105318 | ALOVUDINE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL1160814 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL1160603 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL1160596 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL322925 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL1129 | TRIFLURIDINE | Ki | = | 97000.0 | nM | 4.01 |
| CHEMBL103283 | — | Ki | = | 238000.0 | nM | - |
| CHEMBL105524 | — | Ki | = | 122000.0 | nM | - |
| CHEMBL318153 | EDOXUDINE | Ki | = | 1140000.0 | nM | - |
| CHEMBL1130 | DOXIFLURIDINE | Ki | = | 560000.0 | nM | - |
| CHEMBL103356 | 3-AMINO- 3-DEOXYTHYMIDINE | Ki | = | 230000.0 | nM | - |
| CHEMBL52609 | DOXRIBTIMINE | Ki | = | 715000.0 | nM | - |
| CHEMBL1160818 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL54918 | 5-FLUOROURIDINE | Ki | = | 521000.0 | nM | - |
| CHEMBL1160817 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL102479 | — | Ki | = | 490000.0 | nM | - |
| CHEMBL1160806 | — | Ki | = | 270000.0 | nM | - |
| CHEMBL1160597 | — | Ki | = | 235000.0 | nM | - |
| CHEMBL1160592 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL1160816 | — | Ki | = | 140000.0 | nM | - |
| CHEMBL320200 | — | Ki | = | 140000.0 | nM | - |
| CHEMBL102768 | — | Ki | = | 1900000.0 | nM | - |