Assay Detail
Binding
CHEMBL816320
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Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.78 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112246 | — | — | 1 | 7.57 |
| CHEMBL2112245 | — | — | 1 | 7.34 |
| CHEMBL2369630 | — | — | 1 | 6.14 |
| CHEMBL2369631 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112246 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2112245 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2369630 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL2369631 | — | IC50 | = | 850.0 | nM | 6.07 |