Assay Detail
Binding
CHEMBL816475
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In vitro inhibitory activity against thrombin
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.78 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3215729 | — | — | 1 | 8.21 |
| CHEMBL543817 | — | — | 1 | 7.96 |
| CHEMBL266349 | MELAGATRAN | 4.0 | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3215729 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL543817 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL266349 | MELAGATRAN | IC50 | = | 69.2 | nM | 7.16 |