Assay Detail
Binding
CHEMBL816476
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Inhibition of thrombin (IIa)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel acylguanidine containing thrombin inhibitors with reduced basicity at the P1 moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.22 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332655 | — | — | 1 | 6.96 |
| CHEMBL332907 | — | — | 1 | 6.62 |
| CHEMBL121322 | — | — | 1 | 6.62 |
| CHEMBL121608 | — | — | 1 | 5.96 |
| CHEMBL114715 | INOGATRAN | 2.0 | 1 | 5.89 |
| CHEMBL421057 | — | — | 1 | 5.72 |
| CHEMBL333565 | — | — | 1 | 5.22 |
| CHEMBL118820 | — | — | 1 | 5.00 |
| CHEMBL434412 | — | — | 1 | 4.87 |
| CHEMBL333098 | — | — | 1 | 4.14 |
| CHEMBL339878 | — | — | 1 | 4.13 |
| CHEMBL120012 | — | — | 1 | 4.00 |
| CHEMBL120029 | — | — | 1 | 4.00 |
| CHEMBL421276 | — | — | 1 | 4.00 |
| CHEMBL331930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332655 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL332907 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL121322 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL121608 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL114715 | INOGATRAN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL421057 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL333565 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL118820 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL434412 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL333098 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL339878 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL120012 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL120029 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL421276 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL331930 | — | IC50 | = | 133000.0 | nM | - |