Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL816481

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat 5-alpha reductase isozyme.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Steroid 5-alpha-reductase (CHEMBL2096664)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Pharmacological options in the treatment of benign prostatic hyperplasia.
Kenny B, Ballard S, Blagg J, Fox D.
J Med Chem (1997) 40 : 1293 -1315
PubMed 9135028 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.52 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25193 1 9.00
CHEMBL24470 1 8.77
CHEMBL279745 1 8.30
CHEMBL279206 1 8.05
CHEMBL2298601 1 8.02
CHEMBL2311126 1 7.96
CHEMBL280954 1 7.52
CHEMBL2311127 1 7.46
CHEMBL24091 1 7.33
CHEMBL138225 EPRISTERIDE 2.0 1 7.30
CHEMBL422046 1 7.16
CHEMBL578029 1 7.16
CHEMBL25083 1 6.89
CHEMBL284434 1 6.70
CHEMBL278167 1 6.52
CHEMBL285439 1 6.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25193 IC50 = 1.0 nM 9.00
CHEMBL24470 IC50 = 1.7 nM 8.77
CHEMBL279745 IC50 = 5.0 nM 8.30
CHEMBL279206 IC50 = 9.0 nM 8.05
CHEMBL2298601 IC50 = 9.5 nM 8.02
CHEMBL2311126 IC50 = 11.0 nM 7.96
CHEMBL280954 IC50 = 30.0 nM 7.52
CHEMBL2311127 IC50 = 35.0 nM 7.46
CHEMBL24091 IC50 = 47.0 nM 7.33
CHEMBL138225 EPRISTERIDE IC50 = 50.0 nM 7.30
CHEMBL422046 IC50 = 70.0 nM 7.16
CHEMBL578029 IC50 = 70.0 nM 7.16
CHEMBL25083 IC50 = 128.0 nM 6.89
CHEMBL284434 IC50 = 200.0 nM 6.70
CHEMBL278167 IC50 = 300.0 nM 6.52
CHEMBL285439 IC50 = 588.0 nM 6.23