Assay Detail
Binding
CHEMBL816574
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Inhibitory constant against thrombin (IIa)
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 8.30 | 10.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143418 | — | — | 1 | 10.38 |
| CHEMBL142546 | — | — | 1 | 10.00 |
| CHEMBL143138 | — | — | 1 | 9.57 |
| CHEMBL422299 | — | — | 1 | 9.40 |
| CHEMBL143008 | — | — | 1 | 9.27 |
| CHEMBL19080 | L-375378 | — | 1 | 9.10 |
| CHEMBL142240 | — | — | 1 | 9.05 |
| CHEMBL143824 | — | — | 1 | 9.00 |
| CHEMBL142566 | — | — | 1 | 8.96 |
| CHEMBL143139 | — | — | 1 | 8.96 |
| CHEMBL341909 | — | — | 1 | 8.92 |
| CHEMBL356296 | — | — | 1 | 8.89 |
| CHEMBL143421 | — | — | 1 | 8.80 |
| CHEMBL143024 | — | — | 1 | 8.64 |
| CHEMBL142224 | — | — | 1 | 8.55 |
| CHEMBL342109 | — | — | 1 | 8.44 |
| CHEMBL141889 | — | — | 1 | 8.38 |
| CHEMBL142153 | — | — | 1 | 8.32 |
| CHEMBL30054 | DPOC-4088 | 1.0 | 1 | 8.28 |
| CHEMBL142370 | — | — | 1 | 8.28 |
| CHEMBL143879 | — | — | 1 | 8.17 |
| CHEMBL142776 | — | — | 1 | 8.10 |
| CHEMBL342994 | — | — | 1 | 7.82 |
| CHEMBL143853 | — | — | 1 | 7.82 |
| CHEMBL142106 | — | — | 1 | 7.36 |
| CHEMBL142699 | — | — | 1 | 6.85 |
| CHEMBL145076 | — | — | 1 | 6.55 |
| CHEMBL143060 | — | — | 1 | 6.41 |
| CHEMBL143880 | — | — | 1 | 5.92 |
| CHEMBL347993 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143418 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL142546 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL143138 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL422299 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL143008 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL19080 | L-375378 | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL142240 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL143824 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL142566 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL143139 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL341909 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL356296 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL143421 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL143024 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL142224 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL342109 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL141889 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL142153 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL30054 | DPOC-4088 | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL142370 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL143879 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL142776 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL342994 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL143853 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL142106 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL142699 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL145076 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL143060 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL143880 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL347993 | — | Ki | = | 17000.0 | nM | 4.77 |