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Assay Detail

CHEMBL816580

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against HSV-2 Thymidine Kinase (HSV-2 TK)
ChEMBL ↗
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Thymidine kinase (CHEMBL3415) ↗
Type SINGLE PROTEIN
Organism Human herpesvirus 2

Publication

Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.
Martin JA, Lambert RW, Merrett JH, Parkes KE, Thomas GJ, Baker SJ, Bushnell DJ, Cansfield JE, Dunsdon SJ, Freeman AC, Hopkins RA, Johns IR, Keech E, Simmonite H, Walmsley A, Wong Kai-In P, Holland M.
Bioorg Med Chem Lett (2001) 11 : 1655 -1658
PubMed 11425530 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 8.76 10.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL288683 — — 1 10.05
CHEMBL432111 — — 1 10.00
CHEMBL45114 — — 1 9.96
CHEMBL418258 — — 1 9.96
CHEMBL290528 — — 1 9.96
CHEMBL47089 — — 1 9.89
CHEMBL42459 — — 1 9.89
CHEMBL46821 — — 1 9.85
CHEMBL44047 — — 1 9.85
CHEMBL46884 — — 1 9.85
CHEMBL289560 — — 1 9.72
CHEMBL42820 — — 1 9.72
CHEMBL295657 — — 1 9.68
CHEMBL42389 — — 1 9.68
CHEMBL46633 — — 1 9.55
CHEMBL297081 — — 1 9.37
CHEMBL45424 — — 1 9.15
CHEMBL47041 — — 1 8.92
CHEMBL288569 — — 1 8.85
CHEMBL296195 — — 1 8.59
CHEMBL47094 — — 1 8.48
CHEMBL176768 — — 1 8.28
CHEMBL415909 — — 1 8.08
CHEMBL291187 — — 1 7.52
CHEMBL46502 — — 1 7.36
CHEMBL297987 — — 1 7.22
CHEMBL44535 — — 1 7.16
CHEMBL44996 — — 1 7.05
CHEMBL46739 — — 1 7.05
CHEMBL296690 — — 1 6.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL288683 — IC50 = 0.09 nM 10.05
CHEMBL432111 — IC50 = 0.1 nM 10.00
CHEMBL45114 — IC50 = 0.11 nM 9.96
CHEMBL418258 — IC50 = 0.11 nM 9.96
CHEMBL290528 — IC50 = 0.11 nM 9.96
CHEMBL47089 — IC50 = 0.13 nM 9.89
CHEMBL42459 — IC50 = 0.13 nM 9.89
CHEMBL46821 — IC50 = 0.14 nM 9.85
CHEMBL44047 — IC50 = 0.14 nM 9.85
CHEMBL46884 — IC50 = 0.14 nM 9.85
CHEMBL289560 — IC50 = 0.19 nM 9.72
CHEMBL42820 — IC50 = 0.19 nM 9.72
CHEMBL295657 — IC50 = 0.21 nM 9.68
CHEMBL42389 — IC50 = 0.21 nM 9.68
CHEMBL46633 — IC50 = 0.28 nM 9.55
CHEMBL297081 — IC50 = 0.43 nM 9.37
CHEMBL45424 — IC50 = 0.7 nM 9.15
CHEMBL47041 — IC50 = 1.2 nM 8.92
CHEMBL288569 — IC50 = 1.4 nM 8.85
CHEMBL296195 — IC50 = 2.6 nM 8.59
CHEMBL47094 — IC50 = 3.3 nM 8.48
CHEMBL176768 — IC50 = 5.2 nM 8.28
CHEMBL415909 — IC50 = 8.4 nM 8.08
CHEMBL291187 — IC50 = 30.0 nM 7.52
CHEMBL46502 — IC50 = 44.0 nM 7.36
CHEMBL297987 — IC50 = 60.0 nM 7.22
CHEMBL44535 — IC50 = 70.0 nM 7.16
CHEMBL44996 — IC50 = 90.0 nM 7.05
CHEMBL46739 — IC50 = 90.0 nM 7.05
CHEMBL296690 — IC50 = 140.0 nM 6.85
CHEMBL43963 — IC50 = 300.0 nM 6.52
CHEMBL417528 — IC50 = 420.0 nM 6.38