Assay Detail
Functional
CHEMBL816595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thromboxane synthase inhibitors. Synthesis and pharmacological activity of (R)-, (S)-, and (+/-)-2,2-dimethyl-6-[2-(1H-imidazol-1-yl)-1-[[(4-methoxyphenyl)- methoxy]methyl]ethoxy]hexanoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.03 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51802 | — | — | 1 | 7.44 |
| CHEMBL54268 | — | — | 1 | 6.92 |
| CHEMBL301609 | — | — | 1 | 6.92 |
| CHEMBL53703 | — | — | 1 | 6.41 |
| CHEMBL51367 | — | — | 1 | 6.38 |
| CHEMBL41908 | — | — | 1 | 6.27 |
| CHEMBL299321 | — | — | 1 | 6.25 |
| CHEMBL301189 | — | — | 1 | 6.14 |
| CHEMBL53487 | — | — | 1 | 6.12 |
| CHEMBL412442 | — | — | 1 | 6.00 |
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | 5.89 |
| CHEMBL53700 | — | — | 1 | 5.84 |
| CHEMBL52858 | — | — | 1 | 5.72 |
| CHEMBL53656 | — | — | 1 | 5.40 |
| CHEMBL53480 | — | — | 1 | 5.08 |
| CHEMBL53881 | — | — | 1 | 5.00 |
| CHEMBL296611 | — | — | 1 | 4.75 |
| CHEMBL52568 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51802 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL54268 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL301609 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL53703 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL51367 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL41908 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL299321 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL301189 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL53487 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL412442 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL267473 | DAZOXIBEN | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL53700 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL52858 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL53656 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL53480 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL53881 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL296611 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL52568 | — | IC50 | > | 20000.0 | nM | - |