Assay Detail
Binding
CHEMBL816623
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Tested for inhibitory activity against thromboxane A2 (TXA2) synthetase in microsome of human platelets
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.14 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105139 | — | — | 1 | 8.05 |
| CHEMBL3217077 | — | — | 1 | 8.00 |
| CHEMBL105587 | — | — | 1 | 6.41 |
| CHEMBL105386 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105139 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3217077 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL105587 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL105386 | — | IC50 | = | 810.0 | nM | 6.09 |