Assay Detail
Binding
CHEMBL816624
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets.
53
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 7.66 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338420 | — | — | 1 | 9.00 |
| CHEMBL339269 | — | — | 1 | 8.70 |
| CHEMBL280728 | RIDOGREL | 2.0 | 2 | 8.40 |
| CHEMBL339812 | — | — | 1 | 8.40 |
| CHEMBL130470 | — | — | 1 | 8.40 |
| CHEMBL341094 | — | — | 1 | 8.40 |
| CHEMBL277689 | SAMIXOGREL | 2.0 | 1 | 8.40 |
| CHEMBL65414 | — | — | 2 | 8.40 |
| CHEMBL127380 | — | — | 1 | 8.40 |
| CHEMBL338419 | — | — | 1 | 8.40 |
| CHEMBL126334 | — | — | 1 | 8.40 |
| CHEMBL415519 | — | — | 1 | 8.30 |
| CHEMBL126761 | — | — | 1 | 8.30 |
| CHEMBL126196 | — | — | 1 | 8.30 |
| CHEMBL129635 | — | — | 1 | 8.30 |
| CHEMBL127683 | — | — | 1 | 8.30 |
| CHEMBL339568 | — | — | 1 | 8.30 |
| CHEMBL127357 | — | — | 1 | 8.30 |
| CHEMBL129734 | — | — | 1 | 8.30 |
| CHEMBL338241 | — | — | 1 | 8.30 |
| CHEMBL338360 | — | — | 1 | 8.22 |
| CHEMBL128022 | — | — | 1 | 8.15 |
| CHEMBL340396 | — | — | 1 | 8.15 |
| CHEMBL126577 | — | — | 1 | 8.10 |
| CHEMBL129355 | — | — | 1 | 7.82 |
| CHEMBL338588 | — | — | 1 | 7.72 |
| CHEMBL126185 | — | — | 1 | 7.68 |
| CHEMBL419774 | — | — | 1 | 7.68 |
| CHEMBL338334 | — | — | 1 | 7.68 |
| CHEMBL338546 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338420 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL339269 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL277689 | SAMIXOGREL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL65414 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL341094 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL338419 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL126334 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL127380 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL130470 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL339812 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL129635 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL126761 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL415519 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL129734 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL338241 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL127357 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL127683 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL126196 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL339568 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL338360 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL65414 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL340396 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL128022 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL126577 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL129355 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL338588 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL419774 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL126185 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL338334 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL127017 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL338546 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL419790 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL126333 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL339335 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL126337 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL127212 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL129000 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL128104 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL127681 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL127008 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL126494 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL126373 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL129365 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL127682 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL129030 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL127738 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL125519 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL340504 | — | IC50 | = | 1000.0 | nM | 6.00 |