Assay Detail
Binding
CHEMBL816689
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Compound was tested for inhibitory activity against thrombin
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.60 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329908 | — | — | 1 | 7.09 |
| CHEMBL51173 | — | — | 1 | 6.16 |
| CHEMBL351865 | — | — | 1 | 5.96 |
| CHEMBL350114 | — | — | 1 | 4.55 |
| CHEMBL159435 | — | — | 1 | 4.26 |
| CHEMBL162185 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329908 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL51173 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL351865 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL350114 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL159435 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL162185 | — | IC50 | = | 357000.0 | nM | - |