Assay Detail
Functional
CHEMBL816693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of combined Thromboxane receptor antagonists/thromboxane synthase inhibitors: Pyridine-containing amino-prostanoids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 7.99 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352040 | — | — | 1 | 9.00 |
| CHEMBL159517 | — | — | 1 | 8.60 |
| CHEMBL349625 | — | — | 1 | 8.60 |
| CHEMBL162409 | — | — | 1 | 8.50 |
| CHEMBL161532 | — | — | 1 | 8.50 |
| CHEMBL162133 | — | — | 1 | 8.50 |
| CHEMBL159787 | — | — | 1 | 8.50 |
| CHEMBL345876 | — | — | 1 | 8.50 |
| CHEMBL158576 | — | — | 1 | 8.40 |
| CHEMBL158875 | — | — | 1 | 8.20 |
| CHEMBL350292 | — | — | 1 | 8.20 |
| CHEMBL159860 | — | — | 1 | 8.20 |
| CHEMBL162691 | — | — | 1 | 8.00 |
| CHEMBL433884 | — | — | 1 | 7.90 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 5.40 |
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352040 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL159517 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL349625 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL162409 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL161532 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL162133 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL159787 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL345876 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL158576 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL158875 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL350292 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL159860 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL162691 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL433884 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL280728 | RIDOGREL | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL26820 | (E)-ISBOGREL | Kd | = | 15848.93 | nM | 4.80 |