Assay Detail
Binding
CHEMBL816751
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Inhibitory concentration against radioligand [3H]SQ-29,548 (5 nM) binding to TP receptors in human platelets
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of trimetoquinol derivatives: novel thromboxane A2/prostaglandin H2 antagonists with diminished beta-adrenergic agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.50 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174984 | TRETOQUINOL | 2.0 | 1 | 6.76 |
| CHEMBL170451 | — | — | 1 | 6.47 |
| CHEMBL367394 | — | — | 1 | 5.02 |
| CHEMBL172163 | — | — | 1 | 4.79 |
| CHEMBL173039 | — | — | 1 | 4.46 |
| CHEMBL172042 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174984 | TRETOQUINOL | Ki | = | 173.78 | nM | 6.76 |
| CHEMBL170451 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL367394 | — | Ki | = | 9549.93 | nM | 5.02 |
| CHEMBL172163 | — | Ki | = | 16218.1 | nM | 4.79 |
| CHEMBL173039 | — | Ki | = | 34673.69 | nM | 4.46 |
| CHEMBL172042 | — | Ki | = | 120226.44 | nM | - |