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Assay Detail

CHEMBL816757

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration required to kill 50% of the cells was evaluated under aerobic conditions from chinese hamster V79 cells.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cricetulus griseus
Cell Type V79
Confidence 1 — Organism
Curated By Expert

Target

V79 (CHEMBL614074)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Cyclopropamitosenes, novel bioreductive anticancer agents. Synthesis, electrochemistry, and biological activity of 7-substituted cyclopropamitosenes and related indolequinones.
Cotterill AS, Moody CJ, Mortimer RJ, Norton CL, O'Sullivan N, Stephens MA, Stradiotto NR, Swann E, Stratford IJ.
J Med Chem (1994) 37 : 3834 -3843
PubMed 7966141 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.46 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL75198 1 8.52
CHEMBL127824 1 7.16
CHEMBL273801 1 6.70
CHEMBL125922 1 6.30
CHEMBL105 MITOMYCIN 4.0 1 6.10
CHEMBL421663 1 5.92
CHEMBL126433 1 5.66
CHEMBL331961 1 5.52
CHEMBL127971 1 5.40
CHEMBL127660 1 5.32
CHEMBL338521 1 5.22
CHEMBL125262 1 5.16
CHEMBL127286 1 4.96
CHEMBL127947 1 4.92
CHEMBL329249 1 4.60
CHEMBL124008 1 4.12
CHEMBL340713 1 4.10
CHEMBL126446 1 4.05
CHEMBL126455 1 4.00
CHEMBL127996 1 -
CHEMBL68744 1 -
CHEMBL124924 1 -
CHEMBL124257 1 -
CHEMBL127473 1 -
CHEMBL124990 1 -
CHEMBL341466 1 -
CHEMBL333887 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL75198 IC50 = 3.0 nM 8.52
CHEMBL127824 IC50 = 70.0 nM 7.16
CHEMBL273801 IC50 = 200.0 nM 6.70
CHEMBL125922 IC50 = 500.0 nM 6.30
CHEMBL105 MITOMYCIN IC50 = 800.0 nM 6.10
CHEMBL421663 IC50 = 1200.0 nM 5.92
CHEMBL126433 IC50 = 2200.0 nM 5.66
CHEMBL331961 IC50 = 3000.0 nM 5.52
CHEMBL127971 IC50 = 4000.0 nM 5.40
CHEMBL127660 IC50 = 4800.0 nM 5.32
CHEMBL338521 IC50 = 6000.0 nM 5.22
CHEMBL125262 IC50 = 7000.0 nM 5.16
CHEMBL127286 IC50 = 11000.0 nM 4.96
CHEMBL127947 IC50 = 12000.0 nM 4.92
CHEMBL329249 IC50 = 25000.0 nM 4.60
CHEMBL124008 IC50 = 75000.0 nM 4.12
CHEMBL340713 IC50 = 80000.0 nM 4.10
CHEMBL126446 IC50 = 90000.0 nM 4.05
CHEMBL126455 IC50 = 100000.0 nM 4.00
CHEMBL127996 IC50 = 140000.0 nM -
CHEMBL68744 IC50 = 270000.0 nM -
CHEMBL124924 IC50 = 110000.0 nM -
CHEMBL124257 IC50 = 300000.0 nM -
CHEMBL127473 IC50 = 200000.0 nM -
CHEMBL124990 IC50 = 500000.0 nM -
CHEMBL341466 IC50 = 550000.0 nM -
CHEMBL333887 IC50 = 1000000.0 nM -