Assay Detail
Functional
CHEMBL816758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro TXA2 synthase antagonism through inhibition of collagen induced thromboxane-A2 production in human citreated whole blood
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of combined Thromboxane receptor antagonists/thromboxane synthase inhibitors: Pyridine-containing amino-prostanoids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.50 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 7.50 |
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 7.00 |
| CHEMBL159517 | — | — | 1 | 7.00 |
| CHEMBL158576 | — | — | 1 | 7.00 |
| CHEMBL349625 | — | — | 1 | 7.00 |
| CHEMBL350292 | — | — | 1 | 6.40 |
| CHEMBL433884 | — | — | 1 | 6.20 |
| CHEMBL162691 | — | — | 1 | 6.20 |
| CHEMBL159787 | — | — | 1 | 5.80 |
| CHEMBL159860 | — | — | 1 | 5.80 |
| CHEMBL352040 | — | — | 1 | 5.60 |
| CHEMBL162409 | — | — | 1 | - |
| CHEMBL158875 | — | — | 1 | - |
| CHEMBL161532 | — | — | 1 | - |
| CHEMBL345876 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280728 | RIDOGREL | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL26820 | (E)-ISBOGREL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL159517 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL158576 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL349625 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL350292 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL433884 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL162691 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL159787 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL159860 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL352040 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL162409 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL158875 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL161532 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL345876 | — | IC50 | < | 10000.0 | nM | - |