Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL816885

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration required against tubulin polymerization in the antimicrotubule activity test
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Tubulin (CHEMBL2095182)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.
Xia Y, Yang ZY, Hour MJ, Kuo SC, Xia P, Bastow KF, Nakanishi Y, Namrpoothiri P, Hackl T, Hamel E, Lee HK.
Bioorg Med Chem Lett (2001) 11 : 1193 -1196
PubMed 11354375 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.22 6.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL15778 1 6.36
CHEMBL18351 1 6.08
CHEMBL18290 1 -
CHEMBL67 COMBRETASTATIN A4 -1.0 1 -
CHEMBL18974 1 -
CHEMBL278647 1 -
CHEMBL107 COLCHICINE 4.0 1 -
CHEMBL18670 1 -
CHEMBL18869 1 -
CHEMBL18847 1 -
CHEMBL18258 1 -
CHEMBL273327 1 -
CHEMBL18753 1 -
CHEMBL61 PODOFILOX 4.0 1 -
CHEMBL18688 1 -
CHEMBL276943 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL15778 IC50 = 440.0 nM 6.36
CHEMBL18351 IC50 = 830.0 nM 6.08
CHEMBL18290 IC50 > 40000000.0 nM -
CHEMBL67 COMBRETASTATIN A4 IC50 = 530000.0 nM -
CHEMBL18974 IC50 > 40000000.0 nM -
CHEMBL278647 IC50 = 6500000.0 nM -
CHEMBL107 COLCHICINE IC50 = 800000.0 nM -
CHEMBL18670 IC50 = 8600000.0 nM -
CHEMBL18869 IC50 = 4900000.0 nM -
CHEMBL18847 IC50 > 40000000.0 nM -
CHEMBL18258 IC50 > 40000000.0 nM -
CHEMBL273327 IC50 > 40000000.0 nM -
CHEMBL18753 IC50 > 40000000.0 nM -
CHEMBL61 PODOFILOX IC50 = 460000.0 nM -
CHEMBL18688 IC50 > 40000000.0 nM -
CHEMBL276943 IC50 > 40000000.0 nM -