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Assay Detail

CHEMBL816896

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of aerobic chinese hamster ovary fibroblast UV4 cells using an exposure time of 18 hours
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cricetulus griseus
Cell Type UV4
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
Palmer BD, Wilson WR, Cliffe S, Denny WA.
J Med Chem (1992) 35 : 3214 -3222
PubMed 1507207 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.97 6.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL111459 1 6.57
CHEMBL282252 1 5.92
CHEMBL71857 1 5.57
CHEMBL110985 1 5.24
CHEMBL23330 TRETAZICAR 2.0 1 4.93
CHEMBL304537 1 4.92
CHEMBL441819 1 4.82
CHEMBL19995 1 4.77
CHEMBL107771 1 4.36
CHEMBL107970 1 4.17
CHEMBL45575 1 4.17
CHEMBL109414 1 4.14
CHEMBL107556 1 -
CHEMBL281812 1 -
CHEMBL321681 1 -
CHEMBL19407 1 -
CHEMBL111497 1 -
CHEMBL109191 1 -
CHEMBL420669 1 -
CHEMBL109139 1 -
CHEMBL108554 1 -
CHEMBL321181 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL111459 IC50 = 270.0 nM 6.57
CHEMBL282252 IC50 = 1200.0 nM 5.92
CHEMBL71857 IC50 = 2700.0 nM 5.57
CHEMBL110985 IC50 = 5700.0 nM 5.24
CHEMBL23330 TRETAZICAR IC50 = 11700.0 nM 4.93
CHEMBL304537 IC50 = 12000.0 nM 4.92
CHEMBL441819 IC50 = 15000.0 nM 4.82
CHEMBL19995 IC50 = 17000.0 nM 4.77
CHEMBL107771 IC50 = 44000.0 nM 4.36
CHEMBL107970 IC50 = 68000.0 nM 4.17
CHEMBL45575 IC50 = 68000.0 nM 4.17
CHEMBL109414 IC50 = 72000.0 nM 4.14
CHEMBL107556 IC50 = 5900000.0 nM -
CHEMBL281812 IC50 = 108000.0 nM -
CHEMBL321681 IC50 = 9200000.0 nM -
CHEMBL19407 IC50 = 2950000.0 nM -
CHEMBL111497 IC50 = 4000000.0 nM -
CHEMBL109191 IC50 = 280000.0 nM -
CHEMBL420669 IC50 = 2600000.0 nM -
CHEMBL109139 IC50 = 8400000.0 nM -
CHEMBL108554 IC50 = 3100000.0 nM -
CHEMBL321181 IC50 = 8000000.0 nM -