Assay Detail
Binding
CHEMBL817033
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Tested for its binding affinity against alpha-2 receptor in rat brain membrane
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.60 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306751 | — | — | 2 | 7.96 |
| CHEMBL544765 | — | — | 1 | 7.17 |
| CHEMBL553835 | — | — | 1 | 5.07 |
| CHEMBL542155 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306751 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL306751 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL544765 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL553835 | — | Ki | = | 8582.0 | nM | 5.07 |
| CHEMBL542155 | — | Ki | = | 8810.0 | nM | 5.05 |