Assay Detail
Binding
CHEMBL817034
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Inhibitory activity evaluated against alpha-2,3-sialyltransferase from rat liver
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (CHEMBL3211) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.19 | 4.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307679 | — | — | 1 | 4.19 |
| CHEMBL610554 | — | — | 1 | - |
| CHEMBL609215 | — | — | 1 | - |
| CHEMBL609800 | — | — | 1 | - |
| CHEMBL608928 | — | — | 1 | - |
| CHEMBL608619 | — | — | 1 | - |
| CHEMBL609514 | — | — | 1 | - |
| CHEMBL609516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307679 | — | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL610554 | — | Ki | = | 2300000.0 | nM | - |
| CHEMBL609215 | — | Ki | = | 5300000.0 | nM | - |
| CHEMBL609800 | — | Ki | = | 2300000.0 | nM | - |
| CHEMBL608928 | — | Ki | = | 300000.0 | nM | - |
| CHEMBL608619 | — | Ki | = | 710000.0 | nM | - |
| CHEMBL609514 | — | Ki | = | 5100000.0 | nM | - |
| CHEMBL609516 | — | Ki | = | 900000.0 | nM | - |