Assay Detail
Binding
CHEMBL817081
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]AVP binding to human V2 receptor from murine fibroblast cell line (LV2)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Fibroblast |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4,10-dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.40 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49322 | — | — | 1 | 9.15 |
| CHEMBL49429 | LIXIVAPTAN | 3.0 | 1 | 8.92 |
| CHEMBL48867 | — | — | 1 | 8.17 |
| CHEMBL295014 | — | — | 1 | 8.05 |
| CHEMBL297293 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49322 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL49429 | LIXIVAPTAN | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL48867 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL295014 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL297293 | — | IC50 | = | 19.0 | nM | 7.72 |