Compound Detail
CHEMBL49322
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Basic Information
| ChEMBL ID | CHEMBL49322 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YPBCJEGVEQHBTM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
438.6
MW (Da)
6.06
ALogP
3
HBA
1
HBD
49.4
PSA (Ų)
0.42
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vasopressin V2 receptor CHEMBL1790 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
| Vasopressin V1a receptor CHEMBL1889 | IC50 | 8.07 | 8.07 | 8.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vasopressin V2 receptor | IC50 | = | 0.7 | nM | 9.15 | In vitro inhibition of [3H]AVP binding to human V2 receptor from murine fibrobla... | 10406632 |
| Vasopressin V1a receptor | IC50 | = | 8.5 | nM | 8.07 | In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet mem... | 10406632 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10406632 | 10.1016/s0960-894x(99)00278-4 | Vasopressin V1a receptor | 1 |
| 10406632 | 10.1016/s0960-894x(99)00278-4 | Vasopressin V2 receptor | 1 |
| 10406632 | 10.1016/s0960-894x(99)00278-4 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine