Assay Detail
Binding
CHEMBL817243
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Inhibitory activity against thrombin IIa
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent and selective macrocyclic thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 9.14 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92615 | — | — | 1 | 10.70 |
| CHEMBL96354 | — | — | 1 | 10.30 |
| CHEMBL418965 | — | — | 1 | 10.30 |
| CHEMBL94952 | — | — | 1 | 10.22 |
| CHEMBL327421 | — | — | 1 | 10.05 |
| CHEMBL317393 | — | — | 1 | 9.89 |
| CHEMBL94864 | — | — | 1 | 9.77 |
| CHEMBL316901 | — | — | 1 | 9.70 |
| CHEMBL330560 | — | — | 1 | 9.51 |
| CHEMBL93315 | — | — | 1 | 9.40 |
| CHEMBL352564 | — | — | 1 | 9.40 |
| CHEMBL329912 | — | — | 1 | 9.29 |
| CHEMBL94413 | — | — | 1 | 9.20 |
| CHEMBL96893 | — | — | 1 | 9.13 |
| CHEMBL94622 | — | — | 1 | 8.89 |
| CHEMBL96376 | — | — | 1 | 8.89 |
| CHEMBL96599 | — | — | 1 | 8.68 |
| CHEMBL329266 | — | — | 1 | 8.60 |
| CHEMBL2204325 | — | — | 1 | 8.54 |
| CHEMBL96801 | — | — | 1 | 8.52 |
| CHEMBL94640 | — | — | 1 | 8.30 |
| CHEMBL125181 | — | — | 1 | 8.30 |
| CHEMBL329991 | — | — | 1 | 7.58 |
| CHEMBL317059 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92615 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL96354 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL418965 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL94952 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL327421 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL317393 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL94864 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL316901 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL330560 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL93315 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL352564 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL329912 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL94413 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL96893 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL94622 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL96376 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL96599 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL329266 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL2204325 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL96801 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL94640 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL125181 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL329991 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL317059 | — | Ki | = | 560.0 | nM | 6.25 |