Assay Detail
Binding
CHEMBL817299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human tryptase enzyme
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 5.70 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46809 | — | — | 1 | 10.15 |
| CHEMBL297220 | — | — | 1 | 9.40 |
| CHEMBL75205 | — | — | 1 | 7.08 |
| CHEMBL306372 | — | — | 1 | 6.80 |
| CHEMBL74087 | — | — | 1 | 6.68 |
| CHEMBL72985 | — | — | 1 | 6.52 |
| CHEMBL309262 | — | — | 1 | 6.47 |
| CHEMBL309580 | — | — | 1 | 6.40 |
| CHEMBL74695 | — | — | 1 | 6.06 |
| CHEMBL76769 | — | — | 1 | 6.05 |
| CHEMBL305614 | — | — | 1 | 5.89 |
| CHEMBL310399 | — | — | 1 | 5.58 |
| CHEMBL310411 | — | — | 1 | 5.16 |
| CHEMBL311936 | — | — | 1 | 5.16 |
| CHEMBL73907 | — | — | 1 | 5.16 |
| CHEMBL77525 | — | — | 1 | 5.14 |
| CHEMBL305677 | — | — | 1 | 5.13 |
| CHEMBL311844 | — | — | 1 | 5.01 |
| CHEMBL74494 | — | — | 1 | 5.01 |
| CHEMBL75531 | — | — | 1 | 4.96 |
| CHEMBL74360 | — | — | 1 | 4.96 |
| CHEMBL74428 | — | — | 1 | 4.92 |
| CHEMBL76579 | — | — | 1 | 4.89 |
| CHEMBL74905 | — | — | 1 | 4.80 |
| CHEMBL308808 | — | — | 1 | 4.62 |
| CHEMBL74482 | — | — | 1 | 4.54 |
| CHEMBL76819 | — | — | 1 | 4.38 |
| CHEMBL308376 | — | — | 1 | 4.30 |
| CHEMBL305643 | — | — | 1 | 4.10 |
| CHEMBL77104 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46809 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL297220 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL75205 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL306372 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL74087 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL72985 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL309262 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL309580 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL74695 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL76769 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL305614 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL310399 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL310411 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL311936 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL73907 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL77525 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL305677 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL311844 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL74494 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL75531 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL74360 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL74428 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL76579 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL74905 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL308808 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL74482 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL76819 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL308376 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL305643 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL77104 | — | Ki | = | 370000.0 | nM | - |