Assay Detail
Binding
CHEMBL817324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of oxime neurokinin antagonists: oxime modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 7.91 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355041 | — | — | 1 | 9.30 |
| CHEMBL166921 | — | — | 1 | 9.15 |
| CHEMBL166961 | — | — | 1 | 9.10 |
| CHEMBL352588 | — | — | 1 | 9.10 |
| CHEMBL168272 | — | — | 1 | 8.85 |
| CHEMBL354772 | — | — | 1 | 8.82 |
| CHEMBL66106 | — | — | 1 | 8.80 |
| CHEMBL355295 | — | — | 1 | 8.77 |
| CHEMBL352813 | — | — | 1 | 8.70 |
| CHEMBL166827 | — | — | 1 | 8.57 |
| CHEMBL354771 | — | — | 1 | 8.51 |
| CHEMBL166828 | — | — | 1 | 8.49 |
| CHEMBL262053 | — | — | 1 | 8.46 |
| CHEMBL167994 | — | — | 1 | 8.38 |
| CHEMBL166975 | — | — | 1 | 8.35 |
| CHEMBL165465 | — | — | 1 | 8.32 |
| CHEMBL2112941 | — | — | 1 | 8.30 |
| CHEMBL168144 | — | — | 1 | 8.27 |
| CHEMBL354196 | — | — | 1 | 8.17 |
| CHEMBL353027 | — | — | 1 | 8.07 |
| CHEMBL167606 | — | — | 1 | 8.06 |
| CHEMBL166842 | — | — | 1 | 7.94 |
| CHEMBL169002 | — | — | 1 | 7.85 |
| CHEMBL167613 | — | — | 1 | 7.78 |
| CHEMBL287369 | — | — | 1 | 7.77 |
| CHEMBL354091 | — | — | 1 | 7.72 |
| CHEMBL355868 | — | — | 1 | 7.72 |
| CHEMBL309087 | — | — | 1 | 7.68 |
| CHEMBL353162 | — | — | 1 | 7.64 |
| CHEMBL354822 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355041 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL166921 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL352588 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL166961 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL168272 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL354772 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL66106 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL355295 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL352813 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL166827 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL354771 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL166828 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL262053 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL167994 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL166975 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL165465 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL2112941 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL168144 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL354196 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL353027 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL167606 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL166842 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL169002 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL167613 | — | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL287369 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL354091 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL355868 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL309087 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL353162 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL354822 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL352364 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL170727 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL354892 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL263214 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL167546 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL168437 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL168584 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL350360 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL85980 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL170325 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL167409 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL168769 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL355429 | — | Ki | = | 394.0 | nM | 6.41 |
| CHEMBL352842 | — | Ki | = | 590.0 | nM | 6.23 |