Assay Detail
Functional
CHEMBL817439
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.34 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72511 | — | — | 1 | 7.32 |
| CHEMBL306090 | — | — | 1 | 6.57 |
| CHEMBL76297 | — | — | 1 | 6.03 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 6.00 |
| CHEMBL433314 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72511 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL306090 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL76297 | — | IC50 | = | 928.0 | nM | 6.03 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 1001.0 | nM | 6.00 |
| CHEMBL433314 | — | IC50 | = | 1606.0 | nM | 5.79 |