Assay Detail
Functional
CHEMBL817443
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In vitro inhibition of Ab formation from trinitrophenyl-lipopolysaccharide (TNP-LPS) B-cells.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.39 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59799 | — | — | 1 | 6.52 |
| CHEMBL59800 | — | — | 1 | 6.16 |
| CHEMBL303587 | — | — | 1 | 5.80 |
| CHEMBL432488 | — | — | 1 | 5.36 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 5.29 |
| CHEMBL60338 | — | — | 1 | 4.90 |
| CHEMBL292148 | — | — | 1 | 4.71 |
| CHEMBL291409 | — | — | 1 | 4.37 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | - |
| CHEMBL61763 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59799 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL59800 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL303587 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL432488 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL60338 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL292148 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL291409 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL160 | CYCLOSPORINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL61763 | — | IC50 | > | 50000.0 | nM | - |