Assay Detail
Binding
CHEMBL817536
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Compound was evaluated for in vitro inhibitory activity against polymerization of tubulin into microtubules isolated from bovine brain at 1 mg/mL tubulin concentration
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Combretatroponeshybrids of combretastatin and colchicine. Synthesis and biochemical evaluation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.32 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79720 | — | — | 1 | 5.60 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.54 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.46 |
| CHEMBL156658 | — | — | 1 | 5.07 |
| CHEMBL154628 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79720 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL107 | COLCHICINE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL156658 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL154628 | — | IC50 | = | 12000.0 | nM | 4.92 |