Assay Detail
Binding
CHEMBL817575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibitory activity against bovine trypsin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.34 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55035 | — | — | 1 | 7.52 |
| CHEMBL305809 | — | — | 1 | 6.82 |
| CHEMBL73193 | FIDEXABAN | 2.0 | 1 | 6.55 |
| CHEMBL71175 | — | — | 1 | 6.50 |
| CHEMBL72527 | — | — | 1 | 6.12 |
| CHEMBL72318 | — | — | 1 | 5.96 |
| CHEMBL307989 | — | — | 1 | 5.66 |
| CHEMBL70730 | — | — | 1 | 5.57 |
| CHEMBL71975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55035 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL305809 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL73193 | FIDEXABAN | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL71175 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL72527 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL72318 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL307989 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL70730 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL71975 | — | Ki | > | 5000.0 | nM | - |