Assay Detail
Binding
CHEMBL817580
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against bovine trypsin
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.31 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121982 | — | — | 1 | 6.37 |
| CHEMBL122331 | — | — | 1 | 6.18 |
| CHEMBL421437 | — | — | 1 | 5.92 |
| CHEMBL122488 | — | — | 1 | 5.89 |
| CHEMBL123142 | — | — | 1 | 5.82 |
| CHEMBL337923 | — | — | 1 | 5.60 |
| CHEMBL123942 | — | — | 1 | 5.52 |
| CHEMBL96486 | — | — | 1 | 5.27 |
| CHEMBL122601 | — | — | 1 | 5.08 |
| CHEMBL338788 | — | — | 1 | 5.05 |
| CHEMBL125181 | — | — | 1 | 4.96 |
| CHEMBL122801 | — | — | 1 | 4.92 |
| CHEMBL331908 | — | — | 1 | 4.51 |
| CHEMBL421272 | — | — | 1 | 4.35 |
| CHEMBL331179 | — | — | 1 | 4.25 |
| CHEMBL435012 | — | — | 1 | - |
| CHEMBL331160 | — | — | 1 | - |
| CHEMBL122432 | — | — | 1 | - |
| CHEMBL123759 | — | — | 1 | - |
| CHEMBL121661 | — | — | 1 | - |
| CHEMBL124408 | — | — | 1 | - |
| CHEMBL331181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121982 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL122331 | — | Ki | = | 657.0 | nM | 6.18 |
| CHEMBL421437 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL122488 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL123142 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL337923 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL123942 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL96486 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL122601 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL338788 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL125181 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL122801 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL331908 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL421272 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL331179 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL435012 | — | Ki | = | 767000.0 | nM | - |
| CHEMBL331160 | — | Ki | = | 233000.0 | nM | - |
| CHEMBL122432 | — | Ki | = | 277000.0 | nM | - |
| CHEMBL123759 | — | Ki | = | 384000.0 | nM | - |
| CHEMBL121661 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL124408 | — | Ki | = | 284000.0 | nM | - |
| CHEMBL331181 | — | Ki | = | 144000.0 | nM | - |