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Assay Detail

CHEMBL817581

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition constant against bovine trypsin
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Serine protease 1 (CHEMBL3769)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
Tidwell RR, Geratz JD, Dubovi EJ.
J Med Chem (1983) 26 : 294 -298
PubMed 6219223 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 5.26 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99951 1 7.77
CHEMBL101672 1 5.84
CHEMBL102148 1 5.53
CHEMBL101067 1 5.50
CHEMBL101027 1 5.50
CHEMBL100296 1 5.46
CHEMBL103649 1 5.40
CHEMBL100569 1 5.34
CHEMBL102002 1 5.33
CHEMBL101559 1 5.28
CHEMBL102141 1 5.28
CHEMBL101261 1 5.22
CHEMBL329730 1 5.11
CHEMBL101726 1 5.08
CHEMBL321960 1 4.82
CHEMBL101343 1 4.81
CHEMBL319122 1 4.78
CHEMBL317713 1 4.59
CHEMBL26490 1 4.54
CHEMBL101878 1 4.07
CHEMBL102009 1 -
CHEMBL415700 1 -
CHEMBL321524 1 -
CHEMBL322894 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99951 Ki = 17.0 nM 7.77
CHEMBL101672 Ki = 1440.0 nM 5.84
CHEMBL102148 Ki = 2960.0 nM 5.53
CHEMBL101067 Ki = 3180.0 nM 5.50
CHEMBL101027 Ki = 3200.0 nM 5.50
CHEMBL100296 Ki = 3440.0 nM 5.46
CHEMBL103649 Ki = 4010.0 nM 5.40
CHEMBL100569 Ki = 4590.0 nM 5.34
CHEMBL102002 Ki = 4670.0 nM 5.33
CHEMBL101559 Ki = 5310.0 nM 5.28
CHEMBL102141 Ki = 5310.0 nM 5.28
CHEMBL101261 Ki = 5980.0 nM 5.22
CHEMBL329730 Ki = 7770.0 nM 5.11
CHEMBL101726 Ki = 8290.0 nM 5.08
CHEMBL321960 Ki = 15300.0 nM 4.82
CHEMBL101343 Ki = 15400.0 nM 4.81
CHEMBL319122 Ki = 16800.0 nM 4.78
CHEMBL317713 Ki = 25500.0 nM 4.59
CHEMBL26490 Ki = 29100.0 nM 4.54
CHEMBL101878 Ki = 85300.0 nM 4.07
CHEMBL102009 Ki > 100000.0 nM -
CHEMBL415700 Ki > 1000000.0 nM -
CHEMBL321524 Ki > 1000000.0 nM -
CHEMBL322894 Ki = 137000.0 nM -