Assay Detail
Binding
CHEMBL817584
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against trypsin
49
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 49 | 6.42 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320393 | — | — | 1 | 7.70 |
| CHEMBL322437 | — | — | 1 | 7.66 |
| CHEMBL104970 | — | — | 1 | 7.57 |
| CHEMBL322622 | — | — | 1 | 7.55 |
| CHEMBL322901 | — | — | 1 | 7.36 |
| CHEMBL450936 | — | — | 1 | 7.31 |
| CHEMBL326013 | — | — | 1 | 7.19 |
| CHEMBL107392 | — | — | 1 | 7.17 |
| CHEMBL322165 | — | — | 1 | 7.14 |
| CHEMBL317271 | — | — | 1 | 7.14 |
| CHEMBL107627 | — | — | 1 | 7.01 |
| CHEMBL104426 | — | — | 1 | 6.85 |
| CHEMBL107188 | — | — | 1 | 6.85 |
| CHEMBL97597 | — | — | 1 | 6.85 |
| CHEMBL421411 | — | — | 1 | 6.80 |
| CHEMBL262805 | — | — | 1 | 6.77 |
| CHEMBL322404 | — | — | 1 | 6.75 |
| CHEMBL323304 | — | — | 1 | 6.72 |
| CHEMBL104192 | — | — | 1 | 6.72 |
| CHEMBL105569 | — | — | 1 | 6.72 |
| CHEMBL107132 | — | — | 1 | 6.68 |
| CHEMBL319035 | — | — | 1 | 6.66 |
| CHEMBL318177 | — | — | 2 | 6.66 |
| CHEMBL107522 | — | — | 1 | 6.66 |
| CHEMBL106718 | — | — | 1 | 6.66 |
| CHEMBL420476 | — | — | 1 | 6.66 |
| CHEMBL319868 | — | — | 1 | 6.66 |
| CHEMBL107743 | — | — | 1 | 6.50 |
| CHEMBL321162 | — | — | 1 | 6.50 |
| CHEMBL318175 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320393 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL322437 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL104970 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL322622 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL322901 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL450936 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL326013 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL107392 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL322165 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL317271 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL107627 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL97597 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL107188 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL104426 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL421411 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL262805 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL322404 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL323304 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL104192 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL105569 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL107132 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL319868 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL420476 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL106718 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL319035 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL107522 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL318177 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL107743 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL321162 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL318175 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL104241 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL320937 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL318177 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL107911 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL107282 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL51173 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL317199 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL318304 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL104930 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL104872 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL107429 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL105439 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL318352 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL106111 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL323101 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL104815 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL411506 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL104157 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL320512 | — | Ki | = | 73000.0 | nM | 4.14 |