Assay Detail
Binding
CHEMBL817636
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Inhibitory activity against human Urokinase plasminogen activator receptor (uPAR) was determined
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Urokinase plasminogen activator surface receptor (CHEMBL4883) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, solution structure, and biological evaluation of urokinase type plasminogen activator (uPA)-derived receptor binding domain mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.85 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412236 | — | — | 1 | 7.40 |
| CHEMBL405302 | — | — | 1 | 7.30 |
| CHEMBL405999 | — | — | 1 | 7.22 |
| CHEMBL263158 | — | — | 1 | 7.10 |
| CHEMBL385968 | — | — | 1 | 6.70 |
| CHEMBL412223 | — | — | 1 | 6.16 |
| CHEMBL264653 | — | — | 1 | 6.05 |
| CHEMBL269566 | — | — | 1 | - |
| CHEMBL217327 | — | — | 1 | - |
| CHEMBL437837 | — | — | 1 | - |
| CHEMBL438371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412236 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL405302 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL405999 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL263158 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL385968 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL412223 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL264653 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL269566 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL217327 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL437837 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL438371 | — | IC50 | > | 30000.0 | nM | - |