Compound Detail
CHEMBL405999
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CCCC[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CC(C)C)NC1=O
Basic Information
| ChEMBL ID | CHEMBL405999 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | JUBZJKCXKBCTEM-YKTHBSHESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1138.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Urokinase plasminogen activator surface receptor CHEMBL4883 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Urokinase plasminogen activator surface receptor | IC50 | = | 60.0 | nM | 7.22 | Inhibitory activity against human Urokinase plasminogen activator receptor (uPAR... | 12408709 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12408709 | 10.1021/jm020254q | Urokinase plasminogen activator surface receptor | 1 |
Data from ChEMBL 36 via Core Engine