Assay Detail
Binding
CHEMBL817692
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Ability to displace [3H]haloperidol from rat striatal membranes, in order to measure its intrinsic affinity for the dopamine (DA) receptor
17
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.31 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54661 | Z-FLUPENTIXOL | — | 1 | 8.52 |
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 8.52 |
| CHEMBL1204350 | — | — | 1 | 8.09 |
| CHEMBL12628 | — | — | 1 | 8.06 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.92 |
| CHEMBL2447954 | — | — | 1 | 7.89 |
| CHEMBL1204382 | — | — | 1 | 7.68 |
| CHEMBL1204285 | — | — | 4 | 7.66 |
| CHEMBL1204347 | — | — | 1 | 7.37 |
| CHEMBL1203891 | — | — | 1 | 7.32 |
| CHEMBL1203868 | — | — | 1 | 7.19 |
| CHEMBL1204381 | — | — | 1 | 6.82 |
| CHEMBL433602 | — | — | 1 | 6.72 |
| CHEMBL136562 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54661 | Z-FLUPENTIXOL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL64249 | CLOROTEPINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1204350 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL12628 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2447954 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1204382 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1204285 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1204347 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1203891 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1204285 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1203868 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1204381 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL433602 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1204285 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1204285 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL136562 | — | IC50 | = | 3200.0 | nM | 5.50 |