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Assay Detail

CHEMBL817743

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine pancreatic trypsin
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Trypsin II (CHEMBL4472)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization.
Choi-Sledeski YM, McGarry DG, Green DM, Mason HJ, Becker MR, Davis RS, Ewing WR, Dankulich WP, Manetta VE, Morris RL, Spada AP, Cheney DL, Brown KD, Colussi DJ, Chu V, Heran CL, Morgan SR, Bentley RG, Leadley RJ, Maignan S, Guilloteau JP, Dunwiddie CT, Pauls HW.
J Med Chem (1999) 42 : 3572 -3587
PubMed 10479289 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 6.21 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL332121 1 7.92
CHEMBL431666 1 6.72
CHEMBL93854 1 6.52
CHEMBL332256 1 6.52
CHEMBL333678 1 6.15
CHEMBL327600 1 6.07
CHEMBL332650 1 5.82
CHEMBL120629 1 5.77
CHEMBL119773 1 5.72
CHEMBL119966 1 5.54
CHEMBL420546 1 5.54
CHEMBL118989 1 -
CHEMBL330960 1 -
CHEMBL326959 1 -
CHEMBL324793 1 -
CHEMBL119881 1 -
CHEMBL121575 1 -
CHEMBL434219 1 -
CHEMBL120413 1 -
CHEMBL118392 1 -
CHEMBL331666 1 -
CHEMBL331561 1 -
CHEMBL333548 1 -
CHEMBL326704 1 -
CHEMBL118304 1 -
CHEMBL120384 1 -
CHEMBL433644 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL332121 Ki = 12.0 nM 7.92
CHEMBL431666 Ki = 189.0 nM 6.72
CHEMBL93854 Ki = 305.0 nM 6.52
CHEMBL332256 Ki = 299.0 nM 6.52
CHEMBL333678 Ki = 704.0 nM 6.15
CHEMBL327600 Ki = 853.0 nM 6.07
CHEMBL332650 Ki = 1500.0 nM 5.82
CHEMBL120629 Ki = 1700.0 nM 5.77
CHEMBL119773 Ki = 1900.0 nM 5.72
CHEMBL119966 Ki = 2900.0 nM 5.54
CHEMBL420546 Ki = 2900.0 nM 5.54
CHEMBL118989 Ki > 2900.0 nM -
CHEMBL330960 Ki > 2900.0 nM -
CHEMBL326959 Ki > 2900.0 nM -
CHEMBL324793 Ki > 2900.0 nM -
CHEMBL119881 Ki > 2900.0 nM -
CHEMBL121575 Ki > 2900.0 nM -
CHEMBL434219 Ki > 2900.0 nM -
CHEMBL120413 Ki > 2900.0 nM -
CHEMBL118392 Ki > 2100.0 nM -
CHEMBL331666 Ki > 2900.0 nM -
CHEMBL331561 Ki > 2900.0 nM -
CHEMBL333548 Ki > 2900.0 nM -
CHEMBL326704 Ki > 2900.0 nM -
CHEMBL118304 Ki > 2900.0 nM -
CHEMBL120384 Ki > 2900.0 nM -
CHEMBL433644 Ki > 2900.0 nM -