Assay Detail
Binding
CHEMBL817753
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Inhibitory activity against bovine trypsin
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.21 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71037 | — | — | 1 | 7.14 |
| CHEMBL70813 | — | — | 1 | 6.92 |
| CHEMBL73215 | — | — | 1 | 6.92 |
| CHEMBL431557 | — | — | 1 | 6.85 |
| CHEMBL70766 | — | — | 1 | 6.82 |
| CHEMBL72532 | — | — | 1 | 6.62 |
| CHEMBL70703 | — | — | 1 | 6.51 |
| CHEMBL70350 | — | — | 1 | 6.51 |
| CHEMBL304359 | — | — | 1 | 6.50 |
| CHEMBL72708 | — | — | 1 | 6.50 |
| CHEMBL69394 | — | — | 1 | 6.36 |
| CHEMBL70763 | — | — | 1 | 6.22 |
| CHEMBL71061 | — | — | 1 | 6.13 |
| CHEMBL305738 | — | — | 1 | 6.09 |
| CHEMBL304985 | — | — | 1 | 6.09 |
| CHEMBL302792 | — | — | 1 | 6.02 |
| CHEMBL305457 | — | — | 1 | 6.01 |
| CHEMBL429029 | — | — | 1 | 5.92 |
| CHEMBL72626 | — | — | 1 | 5.92 |
| CHEMBL69558 | — | — | 1 | 5.92 |
| CHEMBL70410 | — | — | 1 | 5.89 |
| CHEMBL419449 | — | — | 1 | 5.89 |
| CHEMBL70917 | — | — | 1 | 5.87 |
| CHEMBL72520 | — | — | 1 | 5.80 |
| CHEMBL70404 | — | — | 1 | 5.75 |
| CHEMBL70523 | — | — | 1 | 5.72 |
| CHEMBL70155 | — | — | 1 | 5.72 |
| CHEMBL303437 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71037 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL70813 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL73215 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL431557 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL70766 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL72532 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL70703 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL70350 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL304359 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL72708 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL69394 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL70763 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL71061 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL305738 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL304985 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL302792 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL305457 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL429029 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL72626 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL69558 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL70410 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL419449 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL70917 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL72520 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL70404 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL70523 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL70155 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL303437 | — | IC50 | = | 5760.0 | nM | 5.24 |