Assay Detail
Binding
CHEMBL817758
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Binding affinity against bovine trypsin
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.90 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159685 | — | — | 1 | 9.60 |
| CHEMBL1159687 | — | — | 1 | 9.52 |
| CHEMBL1159692 | — | — | 1 | 9.51 |
| CHEMBL1159686 | — | — | 1 | 9.24 |
| CHEMBL7895 | — | — | 1 | 9.22 |
| CHEMBL269575 | — | — | 1 | 9.15 |
| CHEMBL268640 | — | — | 1 | 9.10 |
| CHEMBL7860 | — | — | 1 | 8.89 |
| CHEMBL1159689 | — | — | 1 | 8.82 |
| CHEMBL1159694 | — | — | 1 | 8.60 |
| CHEMBL1159690 | — | — | 1 | 8.54 |
| CHEMBL1159688 | — | — | 1 | 8.52 |
| CHEMBL1159691 | — | — | 1 | 8.36 |
| CHEMBL7865 | — | — | 1 | 8.00 |
| CHEMBL451242 | — | — | 1 | 8.00 |
| CHEMBL415298 | — | — | 1 | 7.96 |
| CHEMBL7440 | — | — | 1 | 7.92 |
| CHEMBL268833 | — | — | 1 | 7.17 |
| CHEMBL268824 | — | — | 1 | 7.07 |
| CHEMBL7213 | — | — | 1 | 6.96 |
| CHEMBL8133 | — | — | 1 | 6.82 |
| CHEMBL7418 | — | — | 1 | 6.66 |
| CHEMBL414606 | — | — | 1 | 6.60 |
| CHEMBL7292 | — | — | 1 | 6.27 |
| CHEMBL8079 | — | — | 1 | 6.22 |
| CHEMBL267502 | — | — | 1 | 5.96 |
| CHEMBL7197 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159685 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL1159687 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1159692 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL1159686 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL7895 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL269575 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL268640 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL7860 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1159689 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1159694 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1159690 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1159688 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1159691 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL7865 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL451242 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL415298 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL7440 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL268833 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL268824 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL7213 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL8133 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL7418 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL414606 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL7292 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL8079 | — | Ki | = | 606.0 | nM | 6.22 |
| CHEMBL267502 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL7197 | — | Ki | = | 24000.0 | nM | 4.62 |