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Assay Detail

CHEMBL817769

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Binding
Inhibition of tubulin polymerization interacting at the colchicine binding site.
ChEMBL ↗
103
Total Activities
103
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Tubulin alpha chain (CHEMBL3658) ↗
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.
Zhang SX, Feng J, Kuo SC, Brossi A, Hamel E, Tropsha A, Lee KH.
J Med Chem (2000) 43 : 167 -176
PubMed 10649972 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 103 5.73 6.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50826 — — 1 6.44
CHEMBL50809 — — 1 6.43
CHEMBL301589 — — 1 6.42
CHEMBL15778 — — 1 6.36
CHEMBL50139 — — 1 6.35
CHEMBL51409 — — 1 6.34
CHEMBL299143 — — 1 6.33
CHEMBL48961 — — 1 6.28
CHEMBL51928 — — 1 6.28
CHEMBL50666 — — 1 6.26
CHEMBL49847 — — 1 6.25
CHEMBL279142 — — 1 6.24
CHEMBL48525 — — 1 6.21
CHEMBL49559 — — 1 6.19
CHEMBL18981 THIOCOLCHICINE — 1 6.19
CHEMBL52342 — — 1 6.18
CHEMBL16227 — — 1 6.16
CHEMBL299305 — — 1 6.14
CHEMBL49827 — — 1 6.14
CHEMBL45711 — — 1 6.14
CHEMBL295291 — — 1 6.13
CHEMBL49518 — — 1 6.12
CHEMBL295117 — — 1 6.12
CHEMBL49835 — — 1 6.11
CHEMBL51408 — — 1 6.11
CHEMBL298378 — — 1 6.10
CHEMBL50227 — — 1 6.09
CHEMBL48472 — — 1 6.06
CHEMBL51139 — — 1 6.05
CHEMBL51998 — — 1 6.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50826 — IC50 = 363.08 nM 6.44
CHEMBL50809 — IC50 = 371.54 nM 6.43
CHEMBL301589 — IC50 = 380.19 nM 6.42
CHEMBL15778 — IC50 = 436.52 nM 6.36
CHEMBL50139 — IC50 = 446.68 nM 6.35
CHEMBL51409 — IC50 = 457.09 nM 6.34
CHEMBL299143 — IC50 = 467.74 nM 6.33
CHEMBL51928 — IC50 = 524.81 nM 6.28
CHEMBL48961 — IC50 = 524.81 nM 6.28
CHEMBL50666 — IC50 = 549.54 nM 6.26
CHEMBL49847 — IC50 = 562.34 nM 6.25
CHEMBL279142 — IC50 = 575.44 nM 6.24
CHEMBL48525 — IC50 = 616.6 nM 6.21
CHEMBL18981 THIOCOLCHICINE IC50 = 645.65 nM 6.19
CHEMBL49559 — IC50 = 645.65 nM 6.19
CHEMBL52342 — IC50 = 660.69 nM 6.18
CHEMBL16227 — IC50 = 691.83 nM 6.16
CHEMBL49827 — IC50 = 724.44 nM 6.14
CHEMBL299305 — IC50 = 724.44 nM 6.14
CHEMBL45711 — IC50 = 724.44 nM 6.14
CHEMBL295291 — IC50 = 741.31 nM 6.13
CHEMBL295117 — IC50 = 758.58 nM 6.12
CHEMBL49518 — IC50 = 758.58 nM 6.12
CHEMBL51408 — IC50 = 776.25 nM 6.11
CHEMBL49835 — IC50 = 776.25 nM 6.11
CHEMBL298378 — IC50 = 794.33 nM 6.10
CHEMBL50227 — IC50 = 812.83 nM 6.09
CHEMBL48472 — IC50 = 870.96 nM 6.06
CHEMBL51139 — IC50 = 891.25 nM 6.05
CHEMBL51998 — IC50 = 933.25 nM 6.03
CHEMBL276541 — IC50 = 954.99 nM 6.02
CHEMBL49419 — IC50 = 1000.0 nM 6.00
CHEMBL423845 — IC50 = 1096.48 nM 5.96
CHEMBL298240 — IC50 = 1318.26 nM 5.88
CHEMBL291449 — IC50 = 1412.54 nM 5.85
CHEMBL276340 — IC50 = 1412.54 nM 5.85
CHEMBL299185 — IC50 = 1412.54 nM 5.85
CHEMBL52480 — IC50 = 1412.54 nM 5.85
CHEMBL277239 — IC50 = 1513.56 nM 5.82
CHEMBL45677 — IC50 = 1513.56 nM 5.82
CHEMBL48462 — IC50 = 1513.56 nM 5.82
CHEMBL49016 — IC50 = 1513.56 nM 5.82
CHEMBL48701 — IC50 = 1513.56 nM 5.82
CHEMBL52534 — IC50 = 1513.56 nM 5.82
CHEMBL49621 — IC50 = 1513.56 nM 5.82
CHEMBL277998 — IC50 = 1584.89 nM 5.80
CHEMBL50958 — IC50 = 1698.24 nM 5.77
CHEMBL295520 — IC50 = 1698.24 nM 5.77
CHEMBL50613 — IC50 = 1698.24 nM 5.77
CHEMBL296581 — IC50 = 1819.7 nM 5.74