Assay Detail
Binding
CHEMBL817790
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Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 uM ATP.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.91 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70034 | — | — | 1 | 7.54 |
| CHEMBL67268 | — | — | 1 | 7.05 |
| CHEMBL71985 | — | — | 1 | 6.89 |
| CHEMBL71541 | — | — | 1 | 6.84 |
| CHEMBL71722 | — | — | 1 | 6.79 |
| CHEMBL433097 | — | — | 1 | 6.40 |
| CHEMBL307982 | — | — | 1 | 6.37 |
| CHEMBL66102 | — | — | 1 | 6.30 |
| CHEMBL68082 | — | — | 1 | 6.17 |
| CHEMBL304113 | — | — | 1 | 6.05 |
| CHEMBL69068 | — | — | 1 | 6.05 |
| CHEMBL302279 | — | — | 1 | 5.97 |
| CHEMBL69649 | — | — | 1 | 5.88 |
| CHEMBL66716 | — | — | 1 | 5.80 |
| CHEMBL47940 | — | — | 1 | 5.80 |
| CHEMBL67560 | — | — | 1 | 5.73 |
| CHEMBL302481 | — | — | 1 | 5.70 |
| CHEMBL302281 | — | — | 1 | 5.64 |
| CHEMBL68888 | — | — | 1 | 5.50 |
| CHEMBL303195 | — | — | 1 | 5.48 |
| CHEMBL69868 | — | — | 1 | 5.47 |
| CHEMBL68663 | — | — | 1 | 5.43 |
| CHEMBL69544 | — | — | 1 | 5.37 |
| CHEMBL67211 | — | — | 1 | 5.30 |
| CHEMBL68773 | — | — | 1 | 5.16 |
| CHEMBL67598 | — | — | 1 | 5.04 |
| CHEMBL305748 | — | — | 1 | 5.01 |
| CHEMBL68430 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70034 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL67268 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL71985 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL71541 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL71722 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL433097 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL307982 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL66102 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL68082 | — | IC50 | = | 677.0 | nM | 6.17 |
| CHEMBL304113 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL69068 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL302279 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL69649 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL66716 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL47940 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL67560 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL302481 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL302281 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL68888 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL303195 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL69868 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL68663 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL69544 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL67211 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL68773 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL67598 | — | IC50 | = | 9110.0 | nM | 5.04 |
| CHEMBL305748 | — | IC50 | = | 9820.0 | nM | 5.01 |
| CHEMBL68430 | — | IC50 | = | 16900.0 | nM | 4.77 |