Compound Detail
CHEMBL71722
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL71722 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VKCVHBODVYGOIW-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
369.4
MW (Da)
4.93
ALogP
6
HBA
1
HBD
89.8
PSA (Ų)
0.55
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.79 | 6.79 | 161.0 | 1 |
| Angiopoietin-1 receptor CHEMBL4128 | IC50 | 6.62 | 6.62 | 239.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.34 | 6.0167 | 459.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 161.0 | nM | 6.79 | Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR... | 11012022 |
| Angiopoietin-1 receptor | IC50 | = | 239.0 | nM | 6.62 | Inhibitory activity against tie-2 at a concentration of 5 uM ATP. | 11012022 |
| Unchecked | IC50 | = | 459.0 | nM | 6.34 | Inhibition of p56 Lck tyrosine kinase, in presence of 1 mM ATP | 11012022 |
| Unchecked | IC50 | = | 770.0 | nM | 6.11 | Inhibition of src, in presence of 1 mM ATP | 11012022 |
| Unchecked | IC50 | = | 2530.0 | nM | 5.6 | Inhibition of p56 Lck tyrosine kinase (catalytic domain), in presence of 1 mM AT... | 11012022 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11012022 | 10.1016/s0960-894x(00)00442-x | Unchecked | 3 |
| 11012022 | 10.1016/s0960-894x(00)00442-x | Tyrosine-protein kinase Lck | 2 |
| 11012022 | 10.1016/s0960-894x(00)00442-x | Vascular endothelial growth factor receptor 2 | 1 |
| 11012022 | 10.1016/s0960-894x(00)00442-x | Angiopoietin-1 receptor | 1 |
Data from ChEMBL 36 via Core Engine